The Reef Yucatan is located on one of the prettiest and few virgin beaches of the Gulf of Mexico, in the area of Nuevo Yucatan. Less than one hour to the north of Merida's International Airport, the resort is a few minutes drive from the recently discovered ruins of the Mayan city of Xcambo, the Natural Reserve of Dzilam, and the ecological sanctuaries.

Merida is accessible by land on scheduled tourism buses from Cancun and other cities in the Yucatan Peninsula. By air, it is serviced with direct non-stop flights - primarily from Mexico City, Houston, Miami, and Cancun - on a daily basis.